Water Mediation Is Essential to Nucleation of β-Turn Formation in Peptide Folding Motifs**
نویسندگان
چکیده
Water-mediated bond formation: The structure of the peptide GPG-NH2 has been investigated in aqueous solution to understand the role of water in the formation of a β-turn. Using a combination of neutron diffraction enhanced by isotopic substitution, NMR spectroscopy, and computer simulations, it was found that water is an essential component to initiate folding in solution.
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